The Panthers will open the season on the road, starting off with arch-rival Texas Southern in the Labor Day Classic on Sept. 4. Afterward, Prairie View A&M heads to Incarnate Word (Sept. 11) before its home opener versus Houston Baptist on Sept. 18.
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From there, Prairie View A&M makes the trek to Dallas for the State Fair Classic, taking on Grambling State on Sept. 25. Then, the Panthers host Arkansas-Pine Bluff for an Oct. 2 tilt. After a brief respite, the Panthers make their longest road trip of the season, taking on new SWAC member Bethune-Cookman on Oct. 16.
Prairie View A&M heads to Southern on Oct. 23 and welcomes Alabama State to Panther Stadium on Nov. 6. After a Nov. 13 trip to Alcorn State, the Panthers wrap up the season with a road contest at Texas A&M (Nov. 20) and a home date with Mississippi Valley State on Nov. 27.
Prairie View A&M 2021 Fall Football Schedule
| Date | Opponent |
| Sept. 4 | Texas Southern |
| Sept. 11 | Incarnate Word |
| Sept. 18 | Houston Baptist |
| Sept. 25 | Grambling State |
| Oct. 2 | Arkansas-Pine Bluff |
| Oct. 16 | Bethune-Cookman |
| Oct. 23 | Southern |
| Nov. 6 | Alabama State |
| Nov. 13 | Alcorn State |
| Nov. 20 | Texas A&M |
| Nov. 27 | Mississippi Valley State |
Courtesy: PVAMU Athletics
