Week six of the Division II HBCU football season yielded results that prompted a significant shift in the rankings from the previous week.
The biggest dropoff came from Livingstone, which suffered its first conference loss of the season against Elizabeth City State (first conference win of the year).
Elsewhere, Virginia Union stayed undefeated in conference play with a win over Winston-Salem State, and West Virginia State lost its first conference contest on the final play of the game.
Here are the Ultimate HBCU Sports Division II Football Rankings for Week 6 of the HBCU football season.
| Rank | Team | Week 6 Result | 2025 record |
| 1 | Benedict | 38-28 W vs. Allen | 5-0 |
| 2 | Albany State | 47-6 W vs. Lane | 4-1 |
| 3 | Edward Waters | Idle | 4-1 |
| 4 | Virginia Union | 44-34 W vs. Winston-Salem State | 4-1 |
| 5 | Johnson C. Smith | 31-20 W vs. Virginia State | 5-1 |
| 6 | Kentucky State | 38-17 W vs. Miles | 4-2 |
| 7 | Fayetteville State | 38-10 W vs. Bowie State | 3-3 |
| 8 | West Virginia State | 41-47 L vs. West Liberty | 3-2 |
| 9 | Winston-Salem State | 34-44 L vs. Virginia Union | 3-3 |
| 10 | Livingstone | 27-39 L vs. Elizabeth City State | 3-2 |
